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2023-09-21 18:40
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Company Profile
Xi'an Kintai Biotech Inc.By certification [File Integrity]
Contact:jintaisw(Mr.)
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Area:Beijing
Address:Beijing
Website:http://www.kintai-bio.com/ http://jintaisw.xbxld.com/
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Androtec Andrographolide is a diterpene lactone compound extracted from the plant Andrographis paniculata of the Acanthaceae family. It is the effective ingredient of Andrographis paniculata.It is white square prism or flaky crystal, odorless and bitter. The androglafolide dissolves in boiling ethanol, melts slightly into methanol or ethanol, hardly melts in chloroform, and hardly melts into water or ether.
Modern pharmacological studies have shown that in addition to anti-inflammatory effects, andrographolide also has hypoglycemic, anti-senile dementia, antibacterial, liver protection, anti-tumor, anti-viral and other activities, and is widely used in the field of medicine.
Andrographolide is an organic compound, with molecular formula C20H30O5, and white rhombic or flaky crystal. The main effective ingredient of the natural plant Andrographis paniculata has the effect of dispelling heat and detoxicating, diminishing inflammation and relieving pain. It is known as the natural antibiotic medicine. This product is a diterpenoid lactone compound, which is insoluble in water and can only be administered orally.
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Andrographolide Suppliers
Kintai is committed to producing and providing you with the best Andrographolide. The content of Andrographolide we produce is 98%. If you have other content requirements, please feel free to contact us.
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KinTai Andrographis origin
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Andrographis
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Dried andrographis
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Andrographolide
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Product Quality Standard of Andrographolide:
Product name |
Andrographolide |
Extract source |
Andrographis paniculata whole grass or leaves |
Extraction Solvent |
Ethyl alcohol |
Appearance |
White powder |
Solubility |
Dissolve in boiling ethanol, slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and almost insoluble in water or ether. |
Identification |
TLC , HPLC |
Sulphated Ash |
NMT 0.5% |
Heavy metals |
NMT 20 PPM |
Loss On Drying |
NMT 5.0% |
Powder size |
80Mesh, NLT90% |
Assay of Andrographolide (HPLC test, percent, Standard in House) |
Min. 95.0% |
Residual Solvents |
|
- N-hexane |
NMT 290 PPM |
- Methanol |
NMT 3000 PPM |
- Acetone |
NMT 5000 PPM |
- Ethyl Acetate |
NMT 5000 PPM |
- Ethanol |
NMT 5000 PPM |
Pesticide Residues |
|
- Total DDT (Sum of p,p'-DDD,P,P'-DDE,o,p'-DDT and p,p' -DDT) |
NMT 0.05 PPM |
- Aldrin, Endrin, Dieldrin |
NMT 0.01 PPM |
Microbiological Quality (Total viable aerobic count) |
|
- Bacteria, CFU/g, not more than |
NMT 103 |
- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
Storage |
In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine. |
Shelf life |
24 months |
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Andrographis paniculata leaves are soaked in 95% ethanol, and the resulting ethanol soaked liquid is decolorized with activated carbon, and the concentrated solution after the decolorized liquid is distilled to recover ethanol is left standing to obtain a coarse crystal product, and the coarse crystal is heated to dissolve with 15 times the amount of 95% ethanol, decolorized with activated carbon, and taken while hot Filtrate, stand still and recrystallize to obtain a light yellow recrystallized product, and then wash and refine with distilled water, chloroform and methanol to obtain the finished product of andrographolide.Â
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3.1Â Extract source
Andrographolide is the whole herb extract of Andrographis paniculata (Burm.f) Nees, a 1-year-old herb of the family Acanthaceae. , Elemi, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass and so on. Medicinal plants have the functions of clearing away heat and detoxification, reducing inflammation, reducing swelling and relieving pain.
Leaf-containing diterpene lactone compounds: andrographolide A (deoxyandrographolide) 0.1% or more, andrographolide B (andrographolide 1.5% or more), andrographolide (neoandrographolide) 0.2% or more; and homoandrographolide, Panein lactone. It also contains andrographene, andrographone, andrographol, β-sitosterol-D-glucoside, etc.
In addition to containing andrographolide, it also contains 5-hydroxyl-7,8,2',3'-tetramethoxyflavone, 5-hydroxyl-7,8,2'-trimethoxyflavone , 5,2'--dihydroxyl--7,8--dimethoxyflavone, apigenin--7,4'--dimethyl ether, α--sitosterol, etc.
The whole plant still contains 14--deoxy--11--oxidized andrographolide, 14--deoxy--11,12--didehydroandrographolide, and according to preliminary analysis, it also contains sterol saponins and sugars and condensed tannins and other phenolic substances.
The callus obtained from leaves, twigs, hypocotyls, roots and germs was cultured and separated to obtain three kinds of sesquiterpene lactone compounds: elemenolide A, B and C.
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3.2 Chemical and physical properties
CAS Number |
5508-58-7 |
Molecular Weight |
350.449 |
Density |
1.2±0.1 g/cm3 |
Boiling Point |
557.3±50.0 °C at 760 mmHg |
Molecular Formula |
C20H30O5 |
Melting Point |
229-232ºC |
Common Name |
Andrographolide |
Flash Point |
195.5±23.6 °C |
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4.1 Health Benefits
According to the latest pharmacological experiments,Androtec andrographolide has the following effects on health:
âœ”ï¸ Microbial action of disease resistance agent.
âœ”ï¸ Antipyretic action.
âœ”ï¸ Anti-inflammatory effect.
âœ”ï¸ Antifertility.
âœ”ï¸ Cholagogic and liver protective effects.
âœ”ï¸ Antitumor activity.
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4.2 Application
The main active ingredients of Andrographis paniculata are diterpene lactones, which have anti-inflammatory, antibacterial, and antiviral effects. Among them, andrographolide and dehydroandrographolide have the highest content, and dehydroandrographolide is the most effective one in andrographolide compounds. Drugs made from andrographolide or dehydroandrographolide and their derivatives, such as andrographolide tablets, Chuanhuning injection, Yanhuning injection, etc., have been widely used clinically.
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4.3 Clinical application
(1) Treatment of various infectious diseases;
(2) Treat typhoid fever;
(3)Â Treat pneumonia and other respiratory inflammation;
(4)Â Treatment of infantile dyspepsia and bacillary dysentery;
(5)Â Treatment of neurodermatitis and eczema;
(6) Cure snakebite.
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(1) Take about 1mg of this product, add 3ml of ethanol, dissolve at a low temperature, let it cool, add 1ml of ethanol solution of 1% 3,5-dinitrobenzoic acid ethanol solution, and 2 drops of sodium hydroxide test solution, and it will appear purple.
(2) Take about 10 mg of this product, add 2 ml of ethanol to dissolve at a low temperature, add 2 to 3 drops of ethanol to prepare potassium hydroxide test solution, and gradually turn red.
(3) Take the solution under the content determination item and measure it according to the spectrophotometric method (Appendix IV A of Part Two of the Chinese Pharmacopoeia in 2000), and there is a maximum absorption at the wavelength of 224nm.
(4) The infrared absorption spectrum of this product is consistent with that of the control (spectrum set 301).
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★If you want to get high quality Androtec andrographolide , please feel free to contact us at or feedback in next page.
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http://www.kintai-bio.com/